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TitleSynthesis of 3-alkyl naphthalenes as novel estrogen receptor ligands.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 18, Page 5075-5077, Year 2008
Publish dateJul 14, 2008 (structure data deposition date)
AuthorsFang, J. / Akwabi-Ameyaw, A. / Britton, J.E. / Katamreddy, S.R. / Navas, F. / Miller, A.B. / Williams, S.P. / Gray, D.W. / Orband-Miller, L.A. / Shearin, J. / Heyer, D.
External linksBioorg. Med. Chem. Lett. / PubMed:18722117
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-3dt3:
Human Estrogen receptor alpha LBD with GW368
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-369:
5-(4-hydroxyphenoxy)-6-(3-hydroxyphenyl)-7-methylnaphthalen-2-ol

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / estrogen receptor / nuclear receptor / SERM / transcription factor / alpha-helical sandwich / DNA-binding / Lipid-binding / Metal-binding / Nucleus / Phosphoprotein / Receptor / Steroid-binding / Transcription regulation / Zinc-finger

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