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TitleDiscovery of pyrrolopyridine-pyridone based inhibitors of Met kinase: synthesis, X-ray crystallographic analysis, and biological activities.
Journal, issue, pagesJ. Med. Chem., Vol. 51, Page 5330-5341, Year 2008
Publish dateFeb 28, 2008 (structure data deposition date)
AuthorsKim, K.S. / Zhang, L. / Schmidt, R. / Cai, Z.W. / Wei, D. / Williams, D.K. / Lombardo, L.J. / Trainor, G.L. / Xie, D. / Zhang, Y. ...Kim, K.S. / Zhang, L. / Schmidt, R. / Cai, Z.W. / Wei, D. / Williams, D.K. / Lombardo, L.J. / Trainor, G.L. / Xie, D. / Zhang, Y. / An, Y. / Sack, J.S. / Tokarski, J.S. / Darienzo, C. / Kamath, A. / Marathe, P. / Lippy, J. / Jeyaseelan, R. / Wautlet, B. / Henley, B. / Gullo-Brown, J. / Manne, V. / Hunt, J.T. / Fargnoli, J. / Borzilleri, R.M.
External linksJ. Med. Chem. / PubMed:18690676
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-3ce3:
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor C-MET in complex with a Pyrrolopyridinepyridone based inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-1FN:
1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / RECEPTOR TYROSINE KINASE / SIGNAL TRANSDUCTION / GRB2 / SHC / ATP-BINDING / GLYCOPROTEIN / MEMBRANE / NUCLEOTIDE-BINDING / PHOSPHOPROTEIN / PROTO-ONCOGENE / TRANSMEMBRANE / TYROSINE-PROTEIN KINASE

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