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Structure paper

TitlePyruvate Dehydrogenase Kinase-4 Structures Reveal a Metastable Open Conformation Fostering Robust Core-free Basal Activity
Journal, issue, pagesJ. Biol. Chem., Vol. 283, Page 25305-25315, Year 2008
Publish dateMar 25, 2008 (structure data deposition date)
AuthorsWynn, R.M. / Kato, M. / Chuang, J.L. / Tso, S.-C. / Li, J. / Chuang, D.T.
External linksJ. Biol. Chem. / PubMed:18658136
MethodsX-ray diffraction
Resolution2 - 2.03 Å
Structure data

PDB-2zkj:
Crystal structure of human PDK4-ADP complex
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-3d2r:
Crystal structure of pyruvate dehydrogenase kinase isoform 4 in complex with ADP
Method: X-RAY DIFFRACTION / Resolution: 2.03 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / protein-nucleotide complex / homodimer / GHKL superfamily / Carbohydrate metabolism / Glucose metabolism / Kinase / Mitochondrion / Phosphoprotein / Transit peptide

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