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Title4-Amino-6-arylamino-pyrimidine-5-carbaldehyde hydrazones as potent ErbB-2/EGFR dual kinase inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 18, Page 4615-4619, Year 2008
Publish dateOct 4, 2007 (structure data deposition date)
AuthorsXu, G. / Abad, M.C. / Connolly, P.J. / Neeper, M.P. / Struble, G.T. / Springer, B.A. / Emanuel, S.L. / Pandey, N. / Gruninger, R.H. / Adams, M. ...Xu, G. / Abad, M.C. / Connolly, P.J. / Neeper, M.P. / Struble, G.T. / Springer, B.A. / Emanuel, S.L. / Pandey, N. / Gruninger, R.H. / Adams, M. / Moreno-Mazza, S. / Fuentes-Pesquera, A.R. / Middleton, S.A.
External linksBioorg. Med. Chem. Lett. / PubMed:18653333
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-2rgp:
Structure of EGFR in complex with hydrazone, a potent dual inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HYZ:
N-[1-(3-fluorobenzyl)-1H-indazol-5-yl]-5-[(piperidin-1-ylamino)methyl]pyrimidine-4,6-diamine

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Kinase domain / Alternative splicing / Anti-oncogene / ATP-binding / Cell cycle / Disease mutation / Glycoprotein / Membrane / Nucleotide-binding / Phosphoprotein / Polymorphism / Receptor / Secreted / Transmembrane / Tyrosine-protein kinase / Ubl conjugation

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