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Structure paper

TitleStructural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Zinc-Binding Domain.
Journal, issue, pagesJ. Biol. Chem., Vol. 283, Page 26694-, Year 2008
Publish dateMar 17, 2008 (structure data deposition date)
AuthorsBottomley, M.J. / Lo Surdo, P. / Di Giovine, P. / Cirillo, A. / Scarpelli, R. / Ferrigno, F. / Jones, P. / Neddermann, P. / De Francesco, R. / Steinkuhler, C. ...Bottomley, M.J. / Lo Surdo, P. / Di Giovine, P. / Cirillo, A. / Scarpelli, R. / Ferrigno, F. / Jones, P. / Neddermann, P. / De Francesco, R. / Steinkuhler, C. / Gallinari, P. / Carfi, A.
External linksJ. Biol. Chem. / PubMed:18614528
MethodsX-ray diffraction
Resolution1.8 - 3.3 Å
Structure data

PDB-2vqj:
Structure of HDAC4 catalytic domain bound to a trifluoromethylketone inhbitor
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-2vqm:
Structure of HDAC4 catalytic domain bound to a hydroxamic acid inhbitor
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-2vqo:
Structure of HDAC4 catalytic domain with a gain-of-function muation bound to a trifluoromethylketone inhbitor
Method: X-RAY DIFFRACTION / Resolution: 2.15 Å

PDB-2vqq:
Structure of HDAC4 catalytic domain (a double cysteine-to-alanine mutant) bound to a trifluoromethylketone inhbitor
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-2vqv:
Structure of HDAC4 catalytic domain with a gain-of-function mutation bound to a hydroxamic acid inhibitor
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

PDB-2vqw:
Structure of inhibitor-free HDAC4 catalytic domain (with gain-of- function mutation His332Tyr)
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-DIO:
1,4-DIETHYLENE DIOXIDE

ChemComp-K:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-TFG:
2,2,2-TRIFLUORO-1-{5-[(3-PHENYL-5,6-DIHYDROIMIDAZO[1,2-A]PYRAZIN-7(8H)-YL)CARBONYL]THIOPHEN-2-YL}ETHANE-1,1-DIOL

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-HA3:
N-hydroxy-5-[(3-phenyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)carbonyl]thiophene-2-carboxamide

Source
  • homo sapiens (human)
KeywordsHYDROLASE / INHIBITOR / REPRESSOR / CHROMATIN / COILED COIL / HISTONE DEACETYLASE / TRANSCRIPTION REGULATION / UBL CONJUGATION / CHROMATIN REGULATOR / POLYMORPHISM / TRANSCRIPTION / PHOSPHOPROTEIN / HDAC / ZINC / HDACI / NUCLEUS / CYTOPLASM

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