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TitleA Protein Functional Leap: How a Single Mutation Reverses the Function of the Transcription Regulator Tetr.
Journal, issue, pagesNucleic Acids Res., Vol. 36, Page 4390-, Year 2008
Publish dateJan 2, 2008 (structure data deposition date)
AuthorsResch, M. / Striegl, H. / Henssler, E.M. / Sevvana, M. / Egerer-Sieber, C. / Schiltz, E. / Hillen, W. / Muller, Y.A.
External linksNucleic Acids Res. / PubMed:18587152
MethodsX-ray diffraction
Resolution1.74 Å
Structure data

PDB-2vkv:
TetR (BD) variant L17G with reverse phenotype
Method: X-RAY DIFFRACTION / Resolution: 1.74 Å

Chemicals

ChemComp-TDC:
5A,6-ANHYDROTETRACYCLINE

ChemComp-MG:
Unknown entry

ChemComp-HOH:
WATER

Source
  • escherichia coli (E. coli)
KeywordsTRANSCRIPTION / TRANSCRIPTION REGULATION / DISORDER TO ORDER MECHANISM / ANTIBIOTIC RESISTANCE / HELIX-TURN-HELIX MOTIF / BACTERIAL REPRESSOR / ANHYDROTETRACYCLINE / METAL-BINDING / REVERSE PHENOTYPE / TETR / PLASMID / REPRESSOR / MAGNESIUM / DNA-BINDING

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