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Structure paper

TitleCR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases.
Journal, issue, pagesOncogene, Vol. 27, Page 5797-5807, Year 2008
Publish dateJun 6, 2008 (structure data deposition date)
AuthorsBettayeb, K. / Oumata, N. / Echalier, A. / Ferandin, Y. / Endicott, J.A. / Galons, H. / Meijer, L.
External linksOncogene / PubMed:18574471
MethodsX-ray diffraction
Resolution1.8 - 2.7 Å
Structure data

PDB-3ddp:
Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor CR8
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-3ddq:
Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor roscovitine
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-RC8:
(2R)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol

ChemComp-HOH:
WATER

ChemComp-RRC:
R-ROSCOVITINE / inhibitor*YM

ChemComp-SGM:
MONOTHIOGLYCEROL

Source
  • homo sapiens (human)
  • bos taurus (domestic cattle)
KeywordsTRANSFERASE/CELL CYCLE / Ser/Thr protein kinase; phosphorylation; cell cycle / ATP-binding / Cell division / Mitosis / Nucleotide-binding / Phosphoprotein / Polymorphism / Serine/threonine-protein kinase / Cyclin / Cytoplasm / Nucleus / TRANSFERASE-CELL CYCLE COMPLEX / Ser/Thr protein kinase; transferase; phosphorylation; cell cycle / Cell cycle / Kinase

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