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Structure paper

TitleSmall-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor
Journal, issue, pagesEmbo J., Vol. 27, Page 1985-1994, Year 2008
Publish dateMay 26, 2008 (structure data deposition date)
AuthorsWu, J. / Li, W. / Craddock, B.P. / Foreman, K.W. / Mulvihill, M.J. / Ji, Q.S. / Miller, W.T. / Hubbard, S.R.
External linksEmbo J. / PubMed:18566589
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-3d94:
Crystal structure of the insulin-like growth factor-1 receptor kinase in complex with PQIP
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-D94:
3-[cis-3-(4-methylpiperazin-1-yl)cyclobutyl]-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-8-amine

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / IGF1RK / receptor tyrosine kinase / PQIP / inhibitor / ATP-binding / Glycoprotein / Membrane / Nucleotide-binding / Phosphoprotein / Transmembrane / Tyrosine-protein kinase

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