タイトル | 2-Substituted-16-ene-22-thia-1alpha,25-dihydroxy-26,27-dimethyl-19-norvitamin D3 analogs: Synthesis, biological evaluation, and crystal structure |
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ジャーナル・号・ページ | Bioorg. Med. Chem., Vol. 16, Page 6949-6964, Year 2008 |
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掲載日 | 2008年4月4日 (構造データの登録日) |
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著者 | Shimizu, M. / Miyamoto, Y. / Takaku, H. / Matsuo, M. / Nakabayashi, M. / Masuno, H. / Udagawa, N. / DeLuca, H.F. / Ikura, T. / Ito, N. |
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リンク | Bioorg. Med. Chem. / PubMed:18539034 |
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手法 | X線回折 |
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解像度 | 1.9 - 2 Å |
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構造データ | PDB-2zl9: 2-Substituted-16-ene-22-thia-1alpha,25-dihydroxy-26,27-dimethyl-19-norvitamin D3 analogs: Synthesis, biological evaluation and crystal structure 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-2zla: 2-Substituted-16-ene-22-thia-1alpha,25-dihydroxy-26,27-dimethyl-19-norvitamin D3 analogs: Synthesis, biological evaluation and crystal structure 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-2zlc: 2-Substituted-16-ene-22-thia-1alpha,25-dihydroxy-26,27-dimethyl-19-norvitamin D3 analogs: Synthesis, biological evaluation and crystal structure 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å |
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化合物 | ChemComp-VDA: (1R,2R,3R,5Z)-17-{(1S)-1-[(2-ethyl-2-hydroxybutyl)sulfanyl]ethyl}-2-(2-hydroxyethoxy)-9,10-secoestra-5,7,16-triene-1,3-diol
ChemComp-VDB: (1R,2S,3R,5Z,7E)-17-{(1R)-1-[(2-ethyl-2-hydroxybutyl)sulfanyl]ethyl}-2-(2-hydroxyethoxy)-9,10-secoestra-5,7,16-triene-1,3-diol
ChemComp-VDX: 5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL / カルシトリオ-ル
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由来 | ![](img/tx_mammal.gif) rattus norvegicus (ドブネズミ)
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キーワード | HORMONE / Protein-ligand complex / DNA-binding / Metal-binding / Nucleus / Phosphoprotein / Receptor / Transcription / Transcription regulation / Zinc / Zinc-finger |
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