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TitleSolution Structure of the cGMP Binding GAF Domain from Phosphodiesterase 5: Insights into Nucleotide Selectivity, Dimerization, and cGMP-Dependent Conformational Change.
Journal, issue, pagesJ. Biol. Chem., Vol. 283, Page 22749-22759, Year 2008
Publish dateApr 16, 2008 (structure data deposition date)
AuthorsHeikaus, C.C. / Stout, J.R. / Sekharan, M.R. / Eakin, C.M. / Rajagopal, P. / Brzovic, P.S. / Beavo, J.A. / Klevit, R.E.
External linksJ. Biol. Chem. / PubMed:18534985
MethodsNMR (solution)
Structure data

PDB-2k31:
Solution Structure of cGMP-binding GAF domain of Phosphodiesterase 5
Method: SOLUTION NMR

Chemicals

ChemComp-35G:
GUANOSINE-3',5'-MONOPHOSPHATE

Source
  • mus musculus (house mouse)
KeywordsHYDROLASE / cyclic nucleotide phosphodiesterase / PDE5 / GAF domain / cGMP

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