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Structure paper

TitleCrystal Structure of the Oxazolidinone Antibiotic Linezolid Bound to the 50S Ribosomal Subunit
Journal, issue, pagesJ. Med. Chem., Vol. 51, Page 3353-3356, Year 2008
Publish dateApr 1, 2008 (structure data deposition date)
AuthorsIppolito, J.A. / Kanyo, Z.K. / Wang, D. / Franceschi, F.J. / Moore, P.B. / Steitz, T.A. / Duffy, E.M.
External linksJ. Med. Chem. / PubMed:18494460
MethodsX-ray diffraction
Resolution2.7 Å
Structure data

PDB-3cpw:
The structure of the antibiotic LINEZOLID bound to the large ribosomal subunit of HALOARCULA MARISMORTUI
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-ZLD:
N-{[(5S)-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide / antibiotic*YM

ChemComp-MG:
Unknown entry

ChemComp-K:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-SR:
STRONTIUM ION

ChemComp-CD:
Unknown entry

ChemComp-ACE:
ACETYL GROUP

ChemComp-HOH:
WATER

Source
  • haloarcula marismortui (Halophile)
KeywordsRIBOSOME / LINEZOLID / 50S RIBOSOMAL SUBUNIT / ANTIBIOTIC COMPLEXES / Ribonucleoprotein / Ribosomal protein / RNA-binding / rRNA-binding / tRNA-binding / Metal-binding / Zinc-finger

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