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-Structure paper
Title | Discovery of orally active pyrrolopyridine- and aminopyridine-based Met kinase inhibitors |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 18, Page 3224-3229, Year 2008 |
Publish date | Apr 14, 2008 (structure data deposition date) |
![]() | Cai, Z.-W. / Wei, D. / Schroeder, G.M. / Cornelius, L.A. / Kim, K. / Chen, X.-T. / Schmidt, R.J. / Williams, D.K. / Tokarski, J.S. / An, Y. ...Cai, Z.-W. / Wei, D. / Schroeder, G.M. / Cornelius, L.A. / Kim, K. / Chen, X.-T. / Schmidt, R.J. / Williams, D.K. / Tokarski, J.S. / An, Y. / Sack, J.S. / Manne, V. / Kamath, A. / Zhang, Y. / Marathe, P. / Hunt, J.T. / Lombardo, L.J. / Fargnoli, J. / Borzilleri, R.M. |
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Methods | X-ray diffraction |
Resolution | 2.3 - 2.5 Å |
Structure data | ![]() PDB-3cth: ![]() PDB-3ctj: |
Chemicals | ![]() ChemComp-319: ![]() ChemComp-HOH: ![]() ChemComp-320: |
Source |
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![]() | TRANSFERASE / RECEPTOR TYROSINE KINASE / SIGNAL TRANSDUCTION / GRB2 / SHC / ATP-BINDING / GLYCOPROTEIN / MEMBRANE / NUCLEOTIDE-BINDING / PHOSPHOPROTEIN / PROTO-ONCOGENE / TRANSMEMBRANE / TYROSINE-PROTEIN KINASE |