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TitleDiscovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro)methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 18, Page 3200-3205, Year 2008
Publish dateApr 21, 2008 (structure data deposition date)
AuthorsHan, Y. / Belley, M. / Bayly, C.I. / Colucci, J. / Dufresne, C. / Giroux, A. / Lau, C.K. / Leblanc, Y. / McKay, D. / Therien, M. ...Han, Y. / Belley, M. / Bayly, C.I. / Colucci, J. / Dufresne, C. / Giroux, A. / Lau, C.K. / Leblanc, Y. / McKay, D. / Therien, M. / Wilson, M.C. / Skorey, K. / Chan, C.C. / Scapin, G. / Kennedy, B.P.
External linksBioorg. Med. Chem. Lett. / PubMed:18477508
MethodsX-ray diffraction
Resolution1.6 Å
Structure data

PDB-3cwe:
PTP1B in complex with a phosphonic acid inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-825:
[{2-bromo-4-[(2R)-3-oxo-2,3-diphenylpropyl]phenyl}(difluoro)methyl]phosphonic acid

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / PHOSPHATASE / PHOSPHONATES / DIABETES / INHIBITOR / Acetylation / Endoplasmic reticulum / Membrane / Oxidation / Phosphoprotein / Polymorphism / Protein phosphatase

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