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-Structure paper
Title | Structure-based design and subsequent optimization of 2-tolyl-(1,2,3-triazol-1-yl-4-carboxamide) inhibitors of p38 MAP kinase. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 18, Page 3251-3255, Year 2008 |
Publish date | Apr 14, 2008 (structure data deposition date) |
Authors | Cogan, D.A. / Aungst, R. / Breinlinger, E.C. / Fadra, T. / Goldberg, D.R. / Hao, M.H. / Kroe, R. / Moss, N. / Pargellis, C. / Qian, K.C. / Swinamer, A.D. |
External links | Bioorg. Med. Chem. Lett. / PubMed:18462940 |
Methods | X-ray diffraction |
Resolution | 1.95 Å |
Structure data | PDB-3ctq: |
Chemicals | ChemComp-337: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / Two lobe kinase fold / N-terminal beta-sheet / C-terminal alpha-helix / Alternative splicing / ATP-binding / Cytoplasm / Kinase / Nucleotide-binding / Nucleus / Phosphoprotein / Polymorphism / Serine/threonine-protein kinase |