+検索条件
-Structure paper
タイトル | Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments. |
---|---|
ジャーナル・号・ページ | Bioorg. Med. Chem. Lett., Vol. 18, Page 3446-3455, Year 2008 |
掲載日 | 2008年2月26日 (構造データの登録日) |
![]() | Li, L.S. / Zhou, Y. / Murphy, D.E. / Stankovic, N. / Zhao, J. / Dragovich, P.S. / Bertolini, T. / Sun, Z. / Ayida, B. / Tran, C.V. ...Li, L.S. / Zhou, Y. / Murphy, D.E. / Stankovic, N. / Zhao, J. / Dragovich, P.S. / Bertolini, T. / Sun, Z. / Ayida, B. / Tran, C.V. / Ruebsam, F. / Webber, S.E. / Shah, A.M. / Tsan, M. / Showalter, R.E. / Patel, R. / Lebrun, L.A. / Bartkowski, D.M. / Nolan, T.G. / Norris, D.A. / Kamran, R. / Brooks, J. / Sergeeva, M.V. / Kirkovsky, L. / Zhao, Q. / Kissinger, C.R. |
![]() | ![]() ![]() |
手法 | X線回折 |
解像度 | 2.1 Å |
構造データ | ![]() PDB-3cde: |
化合物 | ![]() ChemComp-N3H: ![]() ChemComp-HOH: |
由来 |
|
![]() | TRANSFERASE / PROTEIN-LIGAND COMPLEX / RNA REPLICATION / RNA-BINDING / RNA-DIRECTED RNA POLYMERASE / ATP-binding / Host-virus interaction / Hydrolase / Metal-binding / Nucleotide-binding / Nucleotidyltransferase / Ribonucleoprotein / Transcription / Transcription regulation / Viral nucleoprotein / Virion |