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Structure paper

Title2-o-phosphorylation of xylose and 6-o-sulfation of galactose in the protein linkage region of glycosaminoglycans influence the glucuronyltransferase-I activity involved in the linkage region synthesis.
Journal, issue, pagesJ. Biol. Chem., Vol. 283, Page 16801-16807, Year 2008
Publish dateApr 15, 2008 (structure data deposition date)
AuthorsTone, Y. / Pedersen, L.C. / Yamamoto, T. / Izumikawa, T. / Kitagawa, H. / Nishihara, J. / Tamura, J. / Negishi, M. / Sugahara, K.
External linksJ. Biol. Chem. / PubMed:18400750
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-3cu0:
human beta 1,3-glucuronyltransferase I (GlcAT-I) in complex with UDP and GAL-GAL(6-SO4)-XYL(2-PO4)-O-SER
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-MN:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-UDP:
URIDINE-5'-DIPHOSPHATE / UDP*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / GlcAT-I / glycosyltransferase / heparan sulfate biosynthesis / Glycoprotein / Golgi apparatus / Manganese / Membrane / Metal-binding / Signal-anchor / Transmembrane

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