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-Structure paper
Title | Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation. |
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Journal, issue, pages | Proc. Natl. Acad. Sci. Usa, Vol. 105, Page 5337-5342, Year 2008 |
Publish date | Nov 19, 2007 (structure data deposition date) |
![]() | Soisson, S.M. / Parthasarathy, G. / Adams, A.D. / Sahoo, S. / Sitlani, A. / Sparrow, C. / Cui, J. / Becker, J.W. |
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Methods | X-ray diffraction |
Resolution | 1.9 Å |
Structure data | ![]() PDB-3bej: |
Chemicals | ![]() ChemComp-YT3: ![]() ChemComp-MUF: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSCRIPTION REGULATOR / FXR / BAR / NR1H4 / bile acid receptor / NHR / nuclear receptor / Activator / Alternative splicing / DNA-binding / Metal-binding / Nucleus / Repressor / Transcription / Transcription regulation / Zinc / Zinc-finger / Acyltransferase / Chromosomal rearrangement / Phosphoprotein / Polymorphism / Proto-oncogene / Transferase / Ubl conjugation / transcription-transferase COMPLEX |