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Structure paper

TitleCrystal structure and functional analysis of tetracenomycin ARO/CYC: implications for cyclization specificity of aromatic polyketides.
Journal, issue, pagesProc. Natl. Acad. Sci. Usa, Vol. 105, Page 5349-5354, Year 2008
Publish dateSep 26, 2007 (structure data deposition date)
AuthorsAmes, B.D. / Korman, T.P. / Zhang, W. / Smith, P. / Vu, T. / Tang, Y. / Tsai, S.C.
External linksProc. Natl. Acad. Sci. Usa / PubMed:18388203
MethodsX-ray diffraction
Resolution1.9 - 2.2 Å
Structure data

PDB-2rer:
Crystal structure of the aromatase/cyclase domain of TcmN from Streptomyces glaucescens
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-2res:
Tetracenomycin ARO/CYC mutant R69A
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-2rez:
Tetracenomycin ARO/CYC NaI Structure
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-ACT:
ACETATE ION

ChemComp-IOD:
IODIDE ION

Source
  • streptomyces glaucescens (bacteria)
KeywordsBIOSYNTHETIC PROTEIN / CYCLASE / AROMATASE / POLYKETIDE / HELIX-GRIP / DEHYDRATASE / ANTICANCER / ANTIBIOTIC / Antibiotic biosynthesis / Methyltransferase / Multifunctional enzyme / Transferase / TETRACENOMYCIN / LYASE / DOUBLE-HOT-DOG

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