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Structure paper

TitleCrystal structure of DNA-bound Co(III) bleomycin B2: Insights on intercalation and minor groove binding.
Journal, issue, pagesProc. Natl. Acad. Sci. Usa, Vol. 105, Page 5052-5056, Year 2008
Publish dateAug 27, 2007 (structure data deposition date)
AuthorsGoodwin, K.D. / Lewis, M.A. / Long, E.C. / Georgiadis, M.M.
External linksProc. Natl. Acad. Sci. Usa / PubMed:18362349
MethodsX-ray diffraction
Resolution2 - 2.8 Å
Structure data

PDB-2r2r:
d(ATTAGTTATAACTAAT) complexed with MMLV RT catalytic fragment
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-2r2s:
Co(III)bleomycinB2 bound to d(ATTAGTTATAACTAAT) complexed with MMLV RT catalytic fragment
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-2r2t:
d(ATTTAGTTAACTAAAT) complexed with MMLV RT catalytic fragment
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-2r2u:
Co(III)bleomycinB2 bithiazole/C-terminal tail domain bound to d(ATTTAGTTAACTAAAT) complexed with MMLV RT catalytic fragment
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-3CO:
COBALT (III) ION

ChemComp-BLB:
BLEOMYCIN B2

ChemComp-BTZ:
N-(4-{[amino(imino)methyl]amino}butyl)-2,4'-bi-1,3-thiazole-4-carboxamide

Source
  • moloney murine leukemia virus
Keywordstransferase/DNA / bleomycin / drug-DNA complex / protein-DNA complex / MMLV RT / Aspartyl protease / DNA recombination / Endonuclease / Multifunctional enzyme / Nuclease / Nucleotidyltransferase / RNA-directed DNA polymerase / transferase-DNA COMPLEX / DNA integration / Transferase / Hydrolase / Protease

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