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TitlePyrazolo-Pyrimidines: A Novel Heterocyclic Scaffold for Potent and Selective P38 Alpha Inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 18, Page 2652-, Year 2008
Publish dateJan 4, 2010 (structure data deposition date)
AuthorsDas, J. / Moquin, R.V. / Pitt, S. / Zhang, R. / Shen, D.R. / Mcintyre, K.W. / Gillooly, K. / Doweyko, A.M. / Sack, J.S. / Zhang, H. ...Das, J. / Moquin, R.V. / Pitt, S. / Zhang, R. / Shen, D.R. / Mcintyre, K.W. / Gillooly, K. / Doweyko, A.M. / Sack, J.S. / Zhang, H. / Kiefer, S.E. / Kish, K. / Mckinnon, M. / Barrish, J.C. / Dodd, J.H. / Schieven, G.L. / Leftheris, K.
External linksBioorg. Med. Chem. Lett. / PubMed:18359226
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-3l8x:
P38 alpha kinase complexed with a pyrazolo-pyrimidine based inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-N4D:
N,4-dimethyl-3-[(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / P38 MAP KINASE / SERINE/THREONINE-PROTEIN KINASE

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