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-Structure paper
Title | Design of an active ultrastable single-chain insulin analog: synthesis, structure, and therapeutic implications. |
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Journal, issue, pages | J. Biol. Chem., Vol. 283, Page 14703-14716, Year 2008 |
Publish date | Jan 11, 2008 (structure data deposition date) |
Authors | Hua, Q.X. / Nakagawa, S.H. / Jia, W. / Huang, K. / Phillips, N.B. / Hu, S.Q. / Weiss, M.A. |
External links | J. Biol. Chem. / PubMed:18332129 |
Methods | NMR (solution) / X-ray diffraction |
Resolution | 1.3 Å |
Structure data | PDB-2jzq: PDB-3bxq: |
Chemicals | ChemComp-ZN: ChemComp-HOH: |
Keywords | HORMONE / SINGLE CHAIN INSULIN / MUTANT / Carbohydrate metabolism / Cleavage on pair of basic residues / Diabetes mellitus / Disease mutation / Glucose metabolism / Pharmaceutical / Secreted / TR transition / Electrostatic block / Protein allostery / Receptor binding |