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| Title | Naphthamides as Novel and Potent Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors: Design, Synthesis and Evaluation |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 51, Page 1649-1667, Year 2008 |
| Publish date | Nov 1, 2007 (structure data deposition date) |
 Authors | Harmange, J.C. / Weiss, M.M. / Germain, J. / Polverino, A.J. / Borg, G. / Bready, J. / Chen, D. / Choquette, D. / Coxon, A. / DeMelfi, T. ...Harmange, J.C. / Weiss, M.M. / Germain, J. / Polverino, A.J. / Borg, G. / Bready, J. / Chen, D. / Choquette, D. / Coxon, A. / DeMelfi, T. / DiPietro, L. / Doerr, N. / Estrada, J. / Flynn, J. / Graceffa, R.F. / Harriman, S.P. / Kaufman, S. / La, D.S. / Long, A. / Martin, M.W. / Neervannan, S. / Patel, V.F. / Potashman, M. / Regal, K. / Roveto, P.M. / Schrag, M.L. / Starnes, C. / Tasker, A. / Teffera, Y. / Wang, L. / White, R.D. / Whittington, D.A. / Zanon, R. |
 External links | J. Med. Chem. / PubMed:18324761 |
| Methods | X-ray diffraction |
| Resolution | 1.75 - 2.75 Å |
| Structure data |  PDB-3b8q:  PDB-3be2: |
| Chemicals |  ChemComp-900:  ChemComp-HOH:  ChemComp-RAJ: |
| Source |
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 Keywords | TRANSFERASE / receptor tyrosine kinase / angiogenesis / ATP-binding / Developmental protein / Differentiation / Glycoprotein / Host-virus interaction / Immunoglobulin domain / Membrane / Nucleotide-binding / Phosphorylation / Polymorphism / Transmembrane / Tyrosine-protein kinase |
homo sapiens (human)