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-Structure paper
Title | Minimal pharmacophoric elements and fragment hopping, an approach directed at molecular diversity and isozyme selectivity. Design of selective neuronal nitric oxide synthase inhibitors. |
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Journal, issue, pages | J. Am. Chem. Soc., Vol. 130, Page 3900-3914, Year 2008 |
Publish date | Oct 22, 2007 (structure data deposition date) |
Authors | Ji, H. / Stanton, B.Z. / Igarashi, J. / Li, H. / Martasek, P. / Roman, L.J. / Poulos, T.L. / Silverman, R.B. |
External links | J. Am. Chem. Soc. / PubMed:18321097 |
Methods | X-ray diffraction |
Resolution | 1.95 - 1.98 Å |
Structure data | PDB-3b3m: PDB-3b3n: |
Chemicals | ChemComp-ACT: ChemComp-ZN: ChemComp-HEM: ChemComp-H4B: ChemComp-JI1: ChemComp-HOH: ChemComp-JI2: |
Source |
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Keywords | OXIDOREDUCTASE / nitric oxide synthase / heme enzyme / inhibitor / Alternative splicing / Calmodulin-binding / Cell projection / FAD / FMN / Iron / Membrane / Metal-binding / NADP |