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-Structure paper
Title | Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation. |
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Journal, issue, pages | J. Med. Chem., Vol. 51, Page 1681-1694, Year 2008 |
Publish date | Jan 16, 2008 (structure data deposition date) |
Authors | DiMauro, E.F. / Newcomb, J. / Nunes, J.J. / Bemis, J.E. / Boucher, C. / Chai, L. / Chaffee, S.C. / Deak, H.L. / Epstein, L.F. / Faust, T. ...DiMauro, E.F. / Newcomb, J. / Nunes, J.J. / Bemis, J.E. / Boucher, C. / Chai, L. / Chaffee, S.C. / Deak, H.L. / Epstein, L.F. / Faust, T. / Gallant, P. / Gore, A. / Gu, Y. / Henkle, B. / Hsieh, F. / Huang, X. / Kim, J.L. / Lee, J.H. / Martin, M.W. / McGowan, D.C. / Metz, D. / Mohn, D. / Morgenstern, K.A. / Oliveira-dos-Santos, A. / Patel, V.F. / Powers, D. / Rose, P.E. / Schneider, S. / Tomlinson, S.A. / Tudor, Y.Y. / Turci, S.M. / Welcher, A.A. / Zhao, H. / Zhu, L. / Zhu, X. |
External links | J. Med. Chem. / PubMed:18321037 |
Methods | X-ray diffraction |
Resolution | 2.2 - 2.3 Å |
Structure data | PDB-3bys: PDB-3byu: |
Chemicals | ChemComp-AM5: ChemComp-HOH: ChemComp-AM6: |
Source |
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Keywords | TRANSFERASE / Lck / Kinase domain / Alternative splicing / ATP-binding / Chromosomal rearrangement / Cytoplasm / Disease mutation / Host-virus interaction / Lipoprotein / Membrane / Myristate / Nucleotide-binding / Palmitate / Phosphoprotein / Proto-oncogene / SH2 domain / SH3 domain / Tyrosine-protein kinase |