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Structure paper

TitleMeCP2 binding to DNA depends upon hydration at methyl-CpG
Journal, issue, pagesMol. Cell, Vol. 29, Page 525-531, Year 2008
Publish dateJan 25, 2008 (structure data deposition date)
AuthorsHo, K.L. / McNae, I.W. / Schmiedeberg, L. / Klose, R.J. / Bird, A.P. / Walkinshaw, M.D.
External linksMol. Cell / PubMed:18313390
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-3c2i:
The Crystal Structure of Methyl-CpG Binding Domain of Human MeCP2 in Complex with a Methylated DNA Sequence from BDNF
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTranscription regulator / water mediated recognition / protein-methylated DNA complex / Asx-ST-motif / Disease mutation / DNA-binding / Nucleus / Phosphoprotein / Repressor

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