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TitleIdentification of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of Met kinase.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 18, Page 1945-1951, Year 2008
Publish dateJan 24, 2008 (structure data deposition date)
AuthorsSchroeder, G.M. / Chen, X.T. / Williams, D.K. / Nirschl, D.S. / Cai, Z.W. / Wei, D. / Tokarski, J.S. / An, Y. / Sack, J. / Chen, Z. ...Schroeder, G.M. / Chen, X.T. / Williams, D.K. / Nirschl, D.S. / Cai, Z.W. / Wei, D. / Tokarski, J.S. / An, Y. / Sack, J. / Chen, Z. / Huynh, T. / Vaccaro, W. / Poss, M. / Wautlet, B. / Gullo-Brown, J. / Kellar, K. / Manne, V. / Hunt, J.T. / Wong, T.W. / Lombardo, L.J. / Fargnoli, J. / Borzilleri, R.M.
External linksBioorg. Med. Chem. Lett. / PubMed:18289854
MethodsX-ray diffraction
Resolution2.17 Å
Structure data

PDB-3c1x:
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-MET in complex with a Pyrrolotriazine based inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.17 Å

Chemicals

ChemComp-CKK:
N-{[4-({5-[(4-aminopiperidin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}oxy)-3-fluorophenyl]carbamoyl}-2-(4-fluorophenyl)acetamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / RECEPTOR TYROSINE KINASE / SIGNAL TRANSDUCTION / GRB2 / SHC / ATP-binding / Glycoprotein / Membrane / Nucleotide-binding / Phosphoprotein / Proto-oncogene / Transmembrane / Tyrosine-protein kinase

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