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TitlePathogenicity of the BRCA1 missense variant M1775K is determined by the disruption of the BRCT phosphopeptide-binding pocket: a multi-modal approach.
Journal, issue, pagesEur. J. Hum. Genet., Vol. 16, Page 820-832, Year 2008
Publish dateOct 7, 2006 (structure data deposition date)
AuthorsTischkowitz, M. / Hamel, N. / Carvalho, M.A. / Birrane, G. / Soni, A. / van Beers, E.H. / Joosse, S.A. / Wong, N. / Novak, D. / Quenneville, L.A. ...Tischkowitz, M. / Hamel, N. / Carvalho, M.A. / Birrane, G. / Soni, A. / van Beers, E.H. / Joosse, S.A. / Wong, N. / Novak, D. / Quenneville, L.A. / Grist, S.A. / Nederlof, P.M. / Goldgar, D.E. / Tavtigian, S.V. / Monteiro, A.N. / Ladias, J.A. / Foulkes, W.D.
External linksEur. J. Hum. Genet. / PubMed:18285836
MethodsX-ray diffraction
Resolution3.6 Å
Structure data

PDB-2ing:
X-ray Structure of the BRCA1 BRCT mutant M1775K
Method: X-RAY DIFFRACTION / Resolution: 3.6 Å

Chemicals

ChemComp-CO:
Unknown entry

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
KeywordsDNA BINDING PROTEIN / Zinc-finger / DNA-binding / DNA repair / Disease mutation / Phosphorylation

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