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-Structure paper
Title | Unusual Binding Mode of the 2S4R Stereoisomer of the Potent Aldose Reductase Cyclic Imide Inhibitor Fidarestat (2S4S) in the 15 K Crystal Structure of the Ternary Complex Refined at 0.78 A Resolution: Implications for the Inhibition Mechanism |
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Journal, issue, pages | J. Med. Chem., Vol. 51, Page 1478-1481, Year 2008 |
Publish date | Nov 13, 2007 (structure data deposition date) |
![]() | Zhao, H.T. / Hazemann, I. / Mitschler, A. / Carbone, V. / Joachimiak, A. / Ginell, S. / Podjarny, A. / El-Kabbani, O. |
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Methods | X-ray diffraction |
Resolution | 0.78 Å |
Structure data | ![]() PDB-3bcj: |
Chemicals | ![]() ChemComp-NAP: ![]() ChemComp-CIT: ![]() ChemComp-FIS: ![]() ChemComp-HOH: |
Source |
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![]() | OXIDOREDUCTASE / Aldo-Keto Reductases / Diabetes / Drug Design / Polyl Pathway / Acetylation / Cataract / Cytoplasm / NADP / Polymorphism |