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Structure paper

TitleStructural basis for EGF receptor inhibition by the therapeutic antibody IMC-11F8.
Journal, issue, pagesStructure, Vol. 16, Page 216-227, Year 2008
Publish dateOct 19, 2007 (structure data deposition date)
AuthorsLi, S. / Kussie, P. / Ferguson, K.M.
External linksStructure / PubMed:18275813
MethodsX-ray diffraction
Resolution2.58 - 3.3 Å
Structure data

PDB-3b2u:
Crystal structure of isolated domain III of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8
Method: X-RAY DIFFRACTION / Resolution: 2.58 Å

PDB-3b2v:
Crystal structure of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM/TRANSFERASE / CELL SURFACE RECEPTOR; GLYCOPROTEIN; ANTIGEN:ANTIBODY COMPLEX; FAB FRAGMENT; ANTITUMOR; DRUG / Anti-oncogene / ATP-binding / Cell cycle / Disease mutation / Kinase / Membrane / Nucleotide-binding / Phosphoprotein / Secreted / Transferase / Transmembrane / Tyrosine-protein kinase / IMMUNE SYSTEM-TRANSFERASE COMPLEX

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