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-Structure paper
Title | Inhibition of carbonic anhydrase II by thioxolone: a mechanistic and structural study. |
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Journal, issue, pages | Biochemistry, Vol. 47, Page 3174-3184, Year 2008 |
Publish date | Feb 5, 2007 (structure data deposition date) |
Authors | Barrese, A.A. / Genis, C. / Fisher, S.Z. / Orwenyo, J.N. / Kumara, M.T. / Dutta, S.K. / Phillips, E. / Kiddle, J.J. / Tu, C. / Silverman, D.N. ...Barrese, A.A. / Genis, C. / Fisher, S.Z. / Orwenyo, J.N. / Kumara, M.T. / Dutta, S.K. / Phillips, E. / Kiddle, J.J. / Tu, C. / Silverman, D.N. / Govindasamy, L. / Agbandje-McKenna, M. / McKenna, R. / Tripp, B.C. |
External links | Biochemistry / PubMed:18266323 |
Methods | X-ray diffraction |
Resolution | 1.6 Å |
Structure data | PDB-2osf: PDB-2osm: |
Chemicals | ChemComp-ZN: ChemComp-TH0: ChemComp-S24: ChemComp-HOH: ChemComp-HTS: |
Source |
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Keywords | LYASE / Carbonic anhydrase II / thioxolone / Therapeutic CA inhibitors / Acetylation / Cytoplasm / Disease mutation / Metal-binding / Polymorphism / Zinc / Human carbonic anhydrase II / 2-hydroxythiophenol |