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TitleA new drug binding subsite on human serum albumin and drug-drug interaction studied by X-ray crystallography
Journal, issue, pagesJ. Struct. Biol., Vol. 162, Page 40-49, Year 2008
Publish dateNov 5, 2007 (structure data deposition date)
AuthorsZhu, L. / Yang, F. / Chen, L. / Meehan, E.J. / Huang, M.
External linksJ. Struct. Biol. / PubMed:18258455
MethodsX-ray diffraction
Resolution2.6 - 2.7 Å
Structure data

PDB-3b9l:
Human serum albumin complexed with myristate and AZT
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-3b9m:
Human serum albumin complexed with myristate, 3'-azido-3'-deoxythymidine (AZT) and salicylic acid
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-MYR:
MYRISTIC ACID

ChemComp-AZZ:
3'-azido-3'-deoxythymidine / medication, antiretroviral*YM

ChemComp-SAL:
2-HYDROXYBENZOIC ACID

Source
  • homo sapiens (human)
KeywordsLIPID BINDING PROTEIN / protein-ligands complex / Cleavage on pair of basic residues / Disease mutation / Glycation / Glycoprotein / Lipid-binding / Metal-binding / Secreted

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