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TitleFunctional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily
Journal, issue, pagesMol. Cell, Vol. 29, Page 191-206, Year 2008
Publish dateOct 30, 2007 (structure data deposition date)
AuthorsSchaaf, G. / Ortlund, E.A. / Tyeryar, K.R. / Mousley, C.J. / Ile, K.E. / Garrett, T.A. / Ren, J. / Woolls, M.J. / Raetz, C.R. / Redinbo, M.R. / Bankaitis, V.A.
External linksMol. Cell / PubMed:18243114
MethodsX-ray diffraction
Resolution1.86 - 2.03 Å
Structure data

PDB-3b74:
Crystal Structure of Yeast Sec14 Homolog Sfh1 in Complex with Phosphatidylethanolamine
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-3b7n:
Crystal Structure of Yeast Sec14 Homolog Sfh1 in Complex with Phosphatidylinositol
Method: X-RAY DIFFRACTION / Resolution: 1.86 Å

PDB-3b7q:
Crystal Structure of Yeast Sec14 Homolog Sfh1 in Complex with Phosphatidylcholine
Method: X-RAY DIFFRACTION / Resolution: 2.03 Å

PDB-3b7z:
Crystal Structure of Yeast Sec14 Homolog Sfh1 in Complex with Phosphatidylcholine or Phosphatidylinositol
Method: X-RAY DIFFRACTION / Resolution: 2.03 Å

Chemicals

ChemComp-PEE:
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine / DOPE, phospholipid*YM

ChemComp-HOH:
WATER

ChemComp-PO4:
PHOSPHATE ION

ChemComp-ACT:
ACETATE ION

ChemComp-B7N:
(1R)-2-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate / phospholipid*YM

ChemComp-6PL:
(4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE / phospholipid*YM

ChemComp-GOL:
GLYCEROL

Source
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsSIGNALING PROTEIN / Sec14 / Golgi / phospholipid / phosphatidylethanolamine / phosphatidylinositol / phosphatidylcholine / phosphatidycholine

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