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Structure paper

TitleStructure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans.
Journal, issue, pagesCell Death Differ., Vol. 15, Page 841-848, Year 2008
Publish dateDec 10, 2007 (structure data deposition date)
AuthorsLinke, K. / Mace, P.D. / Smith, C.A. / Vaux, D.L. / Silke, J. / Day, C.L.
External linksCell Death Differ. / PubMed:18219319
MethodsX-ray diffraction
Resolution2.2 - 2.3 Å
Structure data

PDB-2vje:
Crystal Structure of the MDM2-MDMX RING Domain Heterodimer
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-2vjf:
Crystal Structure of the MDM2-MDMX RING Domain Heterodimer
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-FLC:
CITRATE ANION

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLIGASE / PROTO-ONCOGENE / PHOSPHORYLATION / ALTERNATIVE SPLICING / HOST-VIRUS INTERACTION / UBL CONJUGATION PATHWAY / ZINC-FINGER / POLYMORPHISM / METAL-BINDING / MDM / ZINC / RING / NUCLEUS / CYTOPLASM

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