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-Structure paper
Title | Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 18, Page 999-1005, Year 2008 |
Publish date | Dec 10, 2007 (structure data deposition date) |
Authors | Temperini, C. / Cecchi, A. / Boyle, N.A. / Scozzafava, A. / Cabeza, J.E. / Wentworth, P. / Blackburn, G.M. / Supuran, C.T. |
External links | Bioorg. Med. Chem. Lett. / PubMed:18162396 |
Methods | X-ray diffraction |
Resolution | 1.9 Å |
Structure data | PDB-3bl0: |
Chemicals | ChemComp-ZN: ChemComp-BL0: ChemComp-MBO: ChemComp-HOH: |
Source |
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Keywords | LYASE / carbonic anhydrase / inhibitors / sulfonamide / Acetylation / Cytoplasm / Disease mutation / Metal-binding / Polymorphism / Zinc / LYASE(OXO-ACID) |