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TitleHepatoselectivity of statins: design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 18, Page 1151-1156, Year 2008
Publish dateNov 26, 2007 (structure data deposition date)
AuthorsPark, W.K. / Kennedy, R.M. / Larsen, S.D. / Miller, S. / Roth, B.D. / Song, Y. / Steinbaugh, B.A. / Sun, K. / Tait, B.D. / Kowala, M.C. ...Park, W.K. / Kennedy, R.M. / Larsen, S.D. / Miller, S. / Roth, B.D. / Song, Y. / Steinbaugh, B.A. / Sun, K. / Tait, B.D. / Kowala, M.C. / Trivedi, B.K. / Auerbach, B. / Askew, V. / Dillon, L. / Hanselman, J.C. / Lin, Z. / Lu, G.H. / Robertson, A. / Sekerke, C.
External linksBioorg. Med. Chem. Lett. / PubMed:18155906
MethodsX-ray diffraction
Resolution2.225 Å
Structure data

PDB-3bgl:
Hepatoselectivity of Statins: Design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors
Method: X-RAY DIFFRACTION / Resolution: 2.225 Å

Chemicals

ChemComp-RID:
(3R,5R)-7-[2-(4-fluorophenyl)-5-(1-methylethyl)-4-(morpholin-4-ylsulfonyl)-3-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / CHOLESTEROL BIOSYNTHESIS / HMG-COA / NADPH / STATIN / Alternative splicing / Endoplasmic reticulum / Glycoprotein / Lipid synthesis / Membrane / Peroxisome / Polymorphism / Steroid biosynthesis / Transmembrane

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