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Structure paper

TitleStructure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs.
Journal, issue, pagesScience, Vol. 318, Page 1923-1927, Year 2007
Publish dateOct 4, 2007 (structure data deposition date)
AuthorsLutz, S. / Shankaranarayanan, A. / Coco, C. / Ridilla, M. / Nance, M.R. / Vettel, C. / Baltus, D. / Evelyn, C.R. / Neubig, R.R. / Wieland, T. / Tesmer, J.J.
External linksScience / PubMed:18096806
MethodsX-ray diffraction
Resolution3.5 Å
Structure data

PDB-2rgn:
Crystal Structure of p63RhoGEF complex with Galpha-q and RhoA
Method: X-RAY DIFFRACTION / Resolution: 3.5 Å

Chemicals

ChemComp-ALF:
TETRAFLUOROALUMINATE ION

ChemComp-MG:
Unknown entry

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-HOH:
WATER

Source
  • rattus norvegicus (Norway rat)
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN complex / Heterotrimeric G-protein / small molecular weight G-protein / signaling complex / protein-protein complex / RhoGEF / RhoA / GalphaQ / Galpha-Q / p63RhoGEF / Gq / GTP-binding / Lipoprotein / Nucleotide-binding / Palmitate / Transducer / ADP-ribosylation / Cytoskeleton / Magnesium / Membrane / Methylation / Prenylation / Proto-oncogene

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