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TitleThe structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations.
Journal, issue, pagesScience, Vol. 318, Page 1744-1748, Year 2007
Publish dateSep 20, 2007 (structure data deposition date)
AuthorsHuang, C.H. / Mandelker, D. / Schmidt-Kittler, O. / Samuels, Y. / Velculescu, V.E. / Kinzler, K.W. / Vogelstein, B. / Gabelli, S.B. / Amzel, L.M.
External linksScience / PubMed:18079394
MethodsX-ray diffraction
Resolution3.05 Å
Structure data

PDB-2rd0:
Structure of a human p110alpha/p85alpha complex
Method: X-RAY DIFFRACTION / Resolution: 3.05 Å

Source
  • homo sapiens (human)
KeywordsTransferase/Oncoprotein / Disease mutation / Kinase / Oncogene / Transferase / Host-virus interaction / Phosphorylation / SH2 domain / SH3 domain / Transferase-Oncoprotein COMPLEX

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