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TitleStructural insight into distinct mechanisms of protease inhibition by antibodies.
Journal, issue, pagesProc. Natl. Acad. Sci. Usa, Vol. 104, Page 19784-19789, Year 2007
Publish dateAug 20, 2007 (structure data deposition date)
AuthorsWu, Y. / Eigenbrot, C. / Liang, W.C. / Stawicki, S. / Shia, S. / Fan, B. / Ganesan, R. / Lipari, M.T. / Kirchhofer, D.
External linksProc. Natl. Acad. Sci. Usa / PubMed:18077410
MethodsX-ray diffraction
Resolution2.2 - 3.51 Å
Structure data

PDB-2r0k:
Protease domain of HGFA with inhibitor Fab58
Method: X-RAY DIFFRACTION / Resolution: 3.51 Å

PDB-2r0l:
Short Form HGFA with Inhibitory Fab75
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsHYDROLASE / IMMUNE SYSTEM / serine protease / antibody / inhibitor / EGF-like domain / Glycoprotein / Kringle / Secreted / Zymogen / allosteric inhibitor

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