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Title | 8-(3-(R)-Aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a Highly Potent, Selective, Long-Acting, and Orally Bioavailable DPP-4 Inhibitor for the Treatment of Type 2 Diabetes. |
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Journal, issue, pages | J. Med. Chem., Vol. 50, Page 6450-6453, Year 2007 |
Publish date | Oct 5, 2007 (structure data deposition date) |
Authors | Eckhardt, M. / Langkopf, E. / Mark, M. / Tadayyon, M. / Thomas, L. / Nar, H. / Pfrengle, W. / Guth, B. / Lotz, R. / Sieger, P. ...Eckhardt, M. / Langkopf, E. / Mark, M. / Tadayyon, M. / Thomas, L. / Nar, H. / Pfrengle, W. / Guth, B. / Lotz, R. / Sieger, P. / Fuchs, H. / Himmelsbach, F. |
External links | J. Med. Chem. / PubMed:18052023 |
Methods | X-ray diffraction |
Resolution | 2.6 Å |
Structure data | PDB-2rgu: |
Chemicals | ChemComp-NAG: ChemComp-356: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / peptidase / inhibitor / Aminopeptidase / Glycoprotein / Membrane / Protease / Secreted / Serine protease / Signal-anchor / Transmembrane |