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TitleIdentification and characterization of two amino acids critical for the substrate inhibition of human dehydroepiandrosterone sulfotransferase (SULT2A1)
Journal, issue, pagesMol. Pharmacol., Vol. 73, Page 660-668, Year 2008
Publish dateJul 23, 2007 (structure data deposition date)
AuthorsLu, L.Y. / Hsieh, Y.C. / Liu, M.Y. / Lin, Y.H. / Chen, C.J. / Yang, Y.S.
External linksMol. Pharmacol. / PubMed:18042734
MethodsX-ray diffraction
Resolution2.6 - 3 Å
Structure data

PDB-2qp3:
Identification and Characterization of Two Amino Acids Critical for the Substrate Inhibition of SULT2A1
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-2qp4:
Identification and Characterization of Two Amino Acids Critical for the Substrate Inhibition of SULT2A1
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-AOX:
(3Beta,5alpha)-3-Hydroxyandrostan-17-one / hormone*YM

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Dehydroepiandrosterone(DHEA) / androsterone(ADT) / substrate inhibition / sulfotransferase / substrate binding orientation / Bile acid catabolism / Lipid metabolism / Steroid metabolism

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