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Structure paper

TitleCrystal structure of histone demethylase LSD1 and tranylcypromine at 2.25A
Journal, issue, pagesBiochem. Biophys. Res. Commun., Vol. 366, Page 15-22, Year 2008
Publish dateAug 2, 2006 (structure data deposition date)
AuthorsMimasu, S. / Sengoku, T. / Fukuzawa, S. / Umehara, T. / Yokoyama, S.
External linksBiochem. Biophys. Res. Commun. / PubMed:18039463
MethodsX-ray diffraction
Resolution2.25 - 2.7 Å
Structure data

PDB-2dw4:
Crystal structure of human LSD1 at 2.3 A resolution
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-2ejr:
LSD1-tranylcypromine complex
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-2z3y:
Crystal structure of Lysine-specific demethylase1
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

PDB-2z5u:
Crystal structure of Lysine-specific histone demethylase 1
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

Chemicals

ChemComp-FAD:
FLAVIN-ADENINE DINUCLEOTIDE / FAD*YM

ChemComp-HOH:
WATER

ChemComp-F2N:
[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL (2R,3S,4S)-5-[7,8-DIMETHYL-2,4-DIOXO-5-(3-PHENYLPROPANOYL)-1,3,4,5-TETRAHYDROBENZO[G]PTERIDIN-10(2H)-YL]-2,3,4-TRIHYDROXYPENTYL DIHYDROGEN DIPHOSPHATE

ChemComp-FAJ:
FAD-trans-2-Phenylcyclopropylamine Adduct

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / demethylase / amine oxidase / chromatin / histone / androgen / fad / corepressor / Structural Genomics / NPPSFA / National Project on Protein Structural and Functional Analyses / RIKEN Structural Genomics/Proteomics Initiative / RSGI / Tower domain / LSD1 / Tranylcypromine / Parnate / Alternative splicing / Chromatin regulator / Coiled coil / Nucleus / Phosphorylation / Repressor / Transcription / Transcription regulation / histone demethylase / nucleosome / Lysine-specific

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