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TitleCarbonic anhydrase inhibitors. Interaction of 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 18, Page 152-158, Year 2008
Publish dateOct 24, 2007 (structure data deposition date)
AuthorsGuzel, O. / Temperini, C. / Innocenti, A. / Scozzafava, A. / Salman, A. / Supuran, C.T.
External linksBioorg. Med. Chem. Lett. / PubMed:18024029
MethodsX-ray diffraction
Resolution1.89 Å
Structure data

PDB-3b4f:
Carbonic anhydrase inhibitors. Interaction of 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies
Method: X-RAY DIFFRACTION / Resolution: 1.89 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HG:
Unknown entry

ChemComp-TUO:
2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLYASE / carbonic anhydrase / inhibitors / sulfonamide / Acetylation / Cytoplasm / Disease mutation / Metal-binding / Polymorphism / Zinc / LYASE(OXO-ACID)

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