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Structure paper

TitleBiphenyl amide p38 kinase inhibitors 1: Discovery and binding mode
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 18, Page 318-323, Year 2008
Publish dateOct 12, 2007 (structure data deposition date)
AuthorsAngell, R.M. / Bamborough, P. / Cleasby, A. / Cockerill, S.G. / Jones, K.L. / Mooney, C.J. / Somers, D.O. / Walker, A.L.
External linksBioorg. Med. Chem. Lett. / PubMed:18006306
MethodsX-ray diffraction
Resolution1.8 - 2.5 Å
Structure data

PDB-2zaz:
Crystal structure of P38 in complex with 4-anilino quinoline inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-2zb0:
Crystal structure of P38 in complex with biphenyl amide inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-2zb1:
Crystal structure of P38 in complex with biphenyl amide inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-ACT:
ACETATE ION

ChemComp-GK1:
4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-yl}-1,3-thiazole-2-carbaldehyde

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-GK3:
N-(3-cyanophenyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)-4-biphenylcarboxamide

ChemComp-GK4:
N-(cyclopropylmethyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carboxamide

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Serine/threonine protein kinase / map kinase / P38 / ATP-binding / Nucleotide-binding / Nucleus / Phosphorylation

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