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TitleMechanism of transcriptional stalling at cisplatin-damaged DNA.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 14, Page 1127-1133, Year 2007
Publish dateSep 10, 2007 (structure data deposition date)
AuthorsDamsma, G.E. / Alt, A. / Brueckner, F. / Carell, T. / Cramer, P.
External linksNat. Struct. Mol. Biol. / PubMed:17994106
MethodsX-ray diffraction
Resolution3.8 Å
Structure data

PDB-2r7z:
Cisplatin lesion containing RNA polymerase II elongation complex
Method: X-RAY DIFFRACTION / Resolution: 3.8 Å

Chemicals

ChemComp-CPT:
Cisplatin / medication, chemotherapy*YM

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

Source
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsTRANSCRIPTION/DNA-RNA HYBRID / TRANSFERASE/DNA/RNA / DNA DAMAGE / ZINC-FINGER / DNA-BINDING / PHOSPHORYLATION / CISPLATIN LESION / MISINCORPORATION / RNA POLYMERASE II / TRANSCRIPTION- COUPLED REPAIR / TCR / ARREST / STALLING / DNA LESION / METAL-BINDING / NUCLEAR PROTEIN / TRANSCRIPTION BUBBLE / DAMAGE RECOGNITION / ELONGATION COMPLEX / TRANSFERASE / TRANSCRIPTION / TRANSFERASE-DNA-RNA COMPLEX / TRANSCRIPTION-DNA-RNA HYBRID COMPLEX

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