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Structure paper

TitleStructural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding
Journal, issue, pagesEmbo J., Vol. 26, Page 4902-4912, Year 2007
Publish dateJul 26, 2007 (structure data deposition date)
AuthorsAppleton, B.A. / Wu, P. / Maloney, J. / Yin, J. / Liang, W.C. / Stawicki, S. / Mortara, K. / Bowman, K.K. / Elliott, J.M. / Desmarais, W. ...Appleton, B.A. / Wu, P. / Maloney, J. / Yin, J. / Liang, W.C. / Stawicki, S. / Mortara, K. / Bowman, K.K. / Elliott, J.M. / Desmarais, W. / Bazan, J.F. / Bagri, A. / Tessier-Lavigne, M. / Koch, A.W. / Wu, Y. / Watts, R.J. / Wiesmann, C.
External linksEmbo J. / PubMed:17989695
MethodsX-ray diffraction
Resolution1.8 - 3.1 Å
Structure data

PDB-2qqi:
Crystal Structure of the b1b2 Domains from Human Neuropilin-1
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-2qqj:
Crystal Structure of the b1b2 Domains from Human Neuropilin-2
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-2qqk:
Neuropilin-2 a1a2b1b2 Domains in Complex with a Semaphorin-Blocking Fab
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

PDB-2qql:
Neuropilin-2 a1a2b1b2 Domains in Complex with a Semaphorin-Blocking Fab
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

PDB-2qqm:
Crystal Structure of the a2b1b2 Domains from Human Neuropilin-1
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-2qqn:
Neuropilin-1 b1 Domain in Complex with a VEGF-Blocking Fab
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-2qqo:
Crystal Structure of the a2b1b2 Domains from Human Neuropilin-2
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-CA:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / VEGF receptor / semaphorin receptor / Angiogenesis / Developmental protein / Differentiation / Glycoprotein / Heparan sulfate / Membrane / Neurogenesis / Proteoglycan / Secreted / Transmembrane / HORMONE / Phage-Derived Antibody / calcium-binding domain

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