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-Structure paper
Title | Discovery of an orally efficaceous 4-phenoxypyrrolidine-based BACE-1 inhibitor. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 18, Page 418-422, Year 2008 |
Publish date | Jul 16, 2007 (structure data deposition date) |
Authors | Iserloh, U. / Pan, J. / Stamford, A.W. / Kennedy, M.E. / Zhang, Q. / Zhang, L. / Parker, E.M. / McHugh, N.A. / Favreau, L. / Strickland, C. / Voigt, J. |
External links | Bioorg. Med. Chem. Lett. / PubMed:17980584 |
Methods | X-ray diffraction |
Resolution | 1.89 Å |
Structure data | PDB-2qmg: |
Chemicals | ChemComp-SC6: ChemComp-TAR: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / BACE1 / protease / Alternative splicing / Aspartyl protease / Glycoprotein / Membrane / Transmembrane / Zymogen |