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TitleAnopheles gambiae purine nucleoside phosphorylase: catalysis, structure, and inhibition.
Journal, issue, pagesBiochemistry, Vol. 46, Page 12405-12415, Year 2007
Publish dateMar 13, 2007 (structure data deposition date)
AuthorsTaylor, E.A. / Rinaldo-Matthis, A. / Li, L. / Ghanem, M. / Hazleton, K.Z. / Cassera, M.B. / Almo, S.C. / Schramm, V.L.
External linksBiochemistry / PubMed:17918964
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-2p4s:
Structure of Purine Nucleoside Phosphorylase from Anopheles gambiae in complex with DADMe-ImmH
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-PO4:
PHOSPHATE ION

ChemComp-DIH:
7-[[(3R,4R)-3-(hydroxymethyl)-4-oxidanyl-pyrrolidin-1-ium-1-yl]methyl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one

ChemComp-HOH:
WATER

Source
  • anopheles gambiae (African malaria mosquito)
KeywordsTRANSFERASE / purine nucleoside phosphorylase

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