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TitleClassifying protein kinase structures guides use of ligand-selectivity profiles to predict inactive conformations: Structure of lck/imatinib complex.
Journal, issue, pagesProteins, Vol. 70, Page 1451-1460, Year 2007
Publish dateApr 18, 2007 (structure data deposition date)
AuthorsJacobs, M.D. / Caron, P.R. / Hare, B.J.
External linksProteins / PubMed:17910071
MethodsX-ray diffraction
Resolution2.8 Å
Structure data

PDB-2pl0:
LCK bound to imatinib
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-STI:
4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE / medication, inhibitor*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / kinase phosphorylation

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