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TitleStructure of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) holoenzyme from an orthorhombic crystal form: an insight into the bifunctionality of the enzyme.
Journal, issue, pagesActa Crystallogr. ,Sect. F, Vol. 63, Page 825-830, Year 2007
Publish dateMar 15, 2007 (structure data deposition date)
AuthorsDhagat, U. / Carbone, V. / Chung, R.P. / Schulze-Briese, C. / Endo, S. / Hara, A. / El-Kabbani, O.
External linksActa Crystallogr. ,Sect. F / PubMed:17909281
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-2p5n:
Crystal structure of mouse 17-alpha hydroxysteroid dehydrogenase in complex with coenzyme NADPH
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-NDP:
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsOXIDOREDUCTASE / Aldo-keto reductase / Hydroxysteroid Dehydrogenase / Binary Complex / TIM barrel

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