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-Structure paper
Title | Synthesis and evaluation of substituted benzoisoquinolinones as potent inhibitors of Chk1 kinase. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 17, Page 6280-6285, Year 2007 |
Publish date | Aug 21, 2007 (structure data deposition date) |
![]() | Garbaccio, R.M. / Huang, S. / Tasber, E.S. / Fraley, M.E. / Yan, Y. / Munshi, S. / Ikuta, M. / Kuo, L. / Kreatsoulas, C. / Stirdivant, S. ...Garbaccio, R.M. / Huang, S. / Tasber, E.S. / Fraley, M.E. / Yan, Y. / Munshi, S. / Ikuta, M. / Kuo, L. / Kreatsoulas, C. / Stirdivant, S. / Drakas, B. / Rickert, K. / Walsh, E.S. / Hamilton, K.A. / Buser, C.A. / Hardwick, J. / Mao, X. / Beck, S.C. / Abrams, M.T. / Tao, W. / Lobell, R. / Sepp-Lorenzino, L. / Hartman, G.D. |
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Methods | X-ray diffraction |
Resolution | 1.9 Å |
Structure data | ![]() PDB-2r0u: |
Chemicals | ![]() ChemComp-M54: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSFERASE / Chek1 / Kinase / cell cycle check point / ATP-binding / Cytoplasm / DNA damage / DNA repair / Nucleotide-binding / Nucleus / Phosphorylation / Polymorphism / Serine/threonine-protein kinase / Ubl conjugation |